Timetable
| Evidence Live 2013 - Monday 25th March | ||||
| 08:00 | Registration | |||
| 09:00 | Opening presentation: Welcome to Evidence 2013 ![]()
Fiona Godlee
Editor in Chief, BMJ
Since 1990 Fiona has written on a broad range of issues for BMJ, including the impact of environmental degradation on health, the future of the World Health Organisation, the ethics of academic publication, and the problems of editorial peer review. In 1994 she spent a year at Harvard University as a Harkness Fellow evaluating efforts to bridge the gap between medical research and practice. On returning to the UK, she led the development of BMJ Clinical Evidence, which evaluates the best available evidence on the benefits and harms of treatments and is now provided worldwide to over a million clinicians in 9 languages. In 2000 she moved to Current Science Group to help establish the open access online publisher BioMedCentral as Editorial Director for Medicine. In 2003 she returned to the BMJ Group to head up its new Knowledge division. She has served as President of the World Association of Medical Editors (WAME) and Chair of the Committee on Publication Ethics (COPE) and is co-editor of Peer Review in Health Sciences. Fiona has been editor in chief of the BMJ since 2005 Editor in Chief, BMJ ![]()
Carl Heneghan
Director, Centre for Evidence-Based Medicine, University of Oxford
Carl Heneghan is the Director of the Centre of Evidence-Based Medicine and a General Practitioner. He has had an association with the Centre for Evidence-Based Medicine since 1995. His research projects involve cardiovascular disease, self-monitoring in chronic diseases, and determining the evidence base for treatment of infections. He is a co-applicant on the £3.5million pound NIHR funded centre for Monitoring and Diagnosis in Oxford (MADOX) and works on projects related to oral anticoagulation, the prevention of venous thrombosis and hypertension management, including self monitoring and tele-monitoring. Director, Centre for Evidence-Based Medicine, University of Oxford | |||
| 09:20 | K1 Keynote: Transforming healthcare ![]()
Muir Gray
Chief knowledge Officer of the NHS, Director of The Oxford Centre for Healthcare Transformation
2010 2013 Sir Muir Gray has worked in public health for 35 years. He pioneered Britain's breast and cervical cancer screening programme, and became the Director of the UK National Screening Programme. He set up The National Library for Health and was Director of Clinical Knowledge, Process & Safety for the NHS. He is currently leading the RightCare project for the Department of Health (www.rightcare.nhs.uk) and dire3cts The Oxford Centre for Healthcare Transformation (www.bvhc.co.uk). He was knighted in 2005 for services to the NHS. Chief knowledge Officer of the NHS, Director of The Oxford Centre for Healthcare Transformation | |||
| 09:50 | K2 ![]()
Peter Gøtzsche
Director, The Nordic Cochrane Centre
2013 Professor Peter C Gøtzsche graduated as a master of science in biology and chemistry in 1974 and as a physician 1984. He is a specialist in internal medicine; worked with clinical trials and regulatory affairs in the drug industry 1975-1983, and at hospitals in Copenhagen 1984-95. He cofounded The Cochrane Collaboration in 1993 and established The Nordic Cochrane Centre the same year. He became professor of Clinical Research Design and Analysis in 2010 at the University of Copenhagen. Peter has published more than 50 papers in "the big five" (BMJ, Lancet, JAMA, Ann Intern Med and N Engl J Med) and his scientific works have been cited about 9,000 times. He is author of "Rational Diagnosis and Treatment. Evidence-Based Clinical Decision-Making" (2007) and "Mammography Screening: truth, lies and controversy" (2012). Peter has an interest in statistics and research methodology. He is a member of several groups publishing guidelines for good reporting of research and has co-authored CONSORT for randomised trials (www.consort-statement.org), STROBE for observational studies (www.strobe-statement.org), and PRISMA for systematic reviews and meta-analyses (www.prisma-statement.org). Peter is an editor in the Cochrane Methodology Review Group. Director, The Nordic Cochrane Centre
all sessions
K2
Keynote: Controversies in evidence - the case against screening in breast cancer
![]() Peter Gøtzsche Director, The Nordic Cochrane Centre 25th Mar 2013 - 09:50
Mammography screening is immensely harmful, just like screening for prostate cancer is. A systematic review of countries with organised screening programmes found an overdiagnosis of 52%. This means that a woman can lower her risk of becoming a breast cancer patient by one-third by avoiding going to screening. It has never been shown that screening makes women live longer, and it's not even likely that it does. Declines in breast cancer mortality have coincided with the introduction of effective treatments in all countries and have been totally unrelated to the introduction of screening. Treatment of healthy overdiagnosed women with radiotherapy increases their risk of dying from heart disease and cancer, which is likely to neutralise any possible small effect screening might have on breast cancer mortality. It is time to stop mammography screening. | |||
| 10:20 | K3 ![]()
Patrick M.M. Bossuyt
Professor of Clinical Epidemiology, University of Amsterdam
2011 2013 Patrick M. Bossuyt, PhD is the professor of Clinical Epidemiology at the University of Amsterdam and chaired the department of Clinical Epidemiology, Biostatistics and Bioinformatics at that University for ten years. His scientific work is built on two tracks. Dr Bossuyt collaborates with clinical departments in the Academic Medical Center of the University of Amsterdam in designing and running clinical trials and in translating the results of these studies into guidelines and policy recommendations. Patrick Bossuyt also leads the Biomarker and Test Evaluation Program, to develop the methodology for evaluating medical tests and biomarkers. He spearheaded the STARD initiative for the improved reporting of diagnostic test accuracy studies. Dr Bossuyt has authored and co-authored more than 500 publications in peer reviewed journals and serves on the editorial board of a number of these. Professor of Clinical Epidemiology, University of Amsterdam
all sessions
K3
Keynote: The next frontier for EBM – medical testing
![]() Patrick M.M. Bossuyt Professor of Clinical Epidemiology, University of Amsterdam 25th Mar 2013 - 10:20
Improved diagnostic testing can transform healthcare, but diagnostic evidence is limited in scope and often poorly understood. Patrick Bossuyt leads the Biomarker and Test Evaluation Program, to develop the methodology for evaluating medical tests and biomarkers. He spearheaded the STARD initiative for the improved reporting of diagnostic test accuracy studies. | |||
| 10:50 | Coffee | |||
| 11:20 | A1 Child Health ![]()
Terry Klassen
Director, Manitoba Institute of Child Health
2013 Dr. Klassen became the Director of Research for the Manitoba Institute of Child Health and Associate Dean, Academic in the Faculty of Medicine, University of Manitoba, in charge of the George and Fay Yee Center for Healthcare Innovation in September, 2010. Director, Manitoba Institute of Child Health
all sessions
A1 Child Health
Session: TREKK: an initiative to mobilize knowledge on best paediatric emergency clinical care
![]() Terry Klassen Director, Manitoba Institute of Child Health 25th Mar 2013 - 11:20
The acute care of children in emergency departments has been evolving rapidly over the last 25 years with clinical expertise, training and a growing evidence base as to how to optimally manage these children. Research networks have created new knowledge to guide evidence-based practice in acute respiratory illness, injury and gastroenteritis. However, the care of these children often occurs in an emergency department that is not part of a children’s hospital and hence may not have the same level of access to this new evidence. To address this gap of knowledge translation, Translating Emergency Knowledge for Kids (TREKK) was funded by the Networks of Centers of Excellence program in Canada. ![]()
Ruth Gilbert
Professor of Clinical Epidemiology, Institute of Child Health, University College London
2013 Ruth Gilbert is a clinically qualified and accredited paediatrician trained in epidemiology. She is Professor of Clinical Epidemiology at the Centre for Paediatric Epidemiology & Biostatistics, Director of the Centre for Evidence-Based Child Health, UCL Institute of Child Health and Honorary Consultant Epidemiologist at Great Ormond Street Hospital NHS Trust. Her research has focussed on addressing prognostic, diagnostic, and intervention questions to inform policy on screening, particularly for infections in pregnancy and early childhood. Her expertise is in the use of evidence synthesis methods, involving systematic reviews, meta-analysis, primary studies and analyses of routinely collected data, to address policy questions. Professor of Clinical Epidemiology, Institute of Child Health, University College London
all sessions
A1 Child Health
Session: Challenges in developing an evidence base across children's services
![]() Ruth Gilbert Professor of Clinical Epidemiology, Institute of Child Health, University College London 25th Mar 2013 - 11:20
Recognising and responding to child maltreatment is an area where paediatricians work hand in hand with statutory child protection and judicial services. Expert paediatric opinion is often pivotal to decisions about children’s safety and there is growing emphasis on a rigorous evidence base for signs of abuse. However, robust evidence for the core business of child protection services, placement of children in out-of-home care, remains elusive. This lack of evidence contrasts with the growing numbers of children being placed out of home at an earlier age. I will present findings of a systematic review of out of home care and discuss approaches to randomisation and trial design in the context of judicial decisions about children. ![]()
Sourabh Dutta
Associate Professor in Neonatology, McMaster University
2013 Dr Sourabh Dutta is currently an Associate Professor of Neonatology in the Department of Pediatrics and a staff neonatologist at McMaster Children's Hospital, Ontario, Canada. Dr Dutta received his medical degrees from the All India Institute of Medical Sciences and after working as a Senior Resident in Pediatrics for 3 years, he went to The Children's Hospital at West Mead, Australia for a fellowship in Neonatology. He returned to India and completed his PhD in Neonatology at the Post-Graduate Institute of Medical Education and Research (PGIMER). Prior to his appointment at McMaster, Dr Dutta was working at PGIMER for 12 years, most recently as an Additional Professor. In addition to his clinical knowledge and skills, Dr Dutta has always been very involved in education, teaching pediatrics, neonatology and research methodology. He has taught in research methodology courses conducted by the RCPCH, UK and the NIH, USA. Dr Dutta is an experienced researcher and holds numerous grants as a principal investigator. His area of interest is in neonatal sepsis and he has published extensively on the topic. Associate Professor in Neonatology, McMaster University
all sessions
A1 Child Health
Session: Improving Evidence-based Practice in Neonatology: from India to McMaster
![]() Sourabh Dutta Associate Professor in Neonatology, McMaster University 25th Mar 2013 - 11:20
I have worked as a faculty member both in India and McMaster University, Canada. I compare my experiences with implementing Evidence-based Practice In Neonatology (EPIN) in the developing and developed world. EBM is all about the “care of individual patients”. In India, high workloads preclude thinking about EPIN at the level of the individual patient. There is lack of internet access at the bedside and ward; and making a trip to the office or home is impractical. Lack of local data on baselines risks, pre-test probabilities, and lack of well conducted studies in developing countries often precludes meaningful calculation of NNT’s and post-test probabilities. In private hospitals, lack of medical insurance and loss of wages results in a demand for unrealistic and quick-fix clinical improvements, even if they are by non-evidence-based remedies. In McMaster, there was widespread awareness about EBM, but tendencies to relegate EPIN to a theoretical exercise limited to journal clubs and not used as a practical tool at the bedside. There was an unwillingness to use data generated elsewhere to the extent that it hampered introduction of effective treatment options. As in India, there was a reluctance to make estimates about baseline risks or pre-test probabilities in individual patients. In both setups, physicians preferred published evidence-based guidelines and protocols. Chaired by
Terence Stephenson Nuffield Professor of Child Health, University College London Chaired by Terence Stephenson Nuffield Professor of Child Health, University College London | A2 Building blocks of healthcare guidance ![]()
Peter Davidson
Director of NIHR Evaluation, Trials and Studies Coordinating Centre (NETSCC)
2013 Peter is Director of NIHR Evaluation, Trials and Studies Coordinating Centre (NETSCC), HTA (Health Technology Assessment programme) and was first appointed in 2006. He was previously a senior lecturer (visiting) at the Wessex Institute and a consultant in Public Health Medicine at Southampton City PCT. In his earlier career he was a principal in general practice. Peter has also lead the HTA Clinical Trials work stream and was series editor of the Health Technology Assessment journal. He has a research interest in systematic reviews. Director of NIHR Evaluation, Trials and Studies Coordinating Centre (NETSCC)
all sessions
A2 Building blocks of healthcare guidance
Session: Using health technology assessments to identify, evaluate and combine research evidence
![]() Peter Davidson Director of NIHR Evaluation, Trials and Studies Coordinating Centre (NETSCC) 25th Mar 2013 - 11:20
Peter is Director of NETSCC, HTA (Health Technology Assessment programme) and was first appointed in 2006. He has also led the HTA Clinical Trials work stream and was series editor of the Health Technology Assessment journal. The HTA Programme produces independent research about the effectiveness of different healthcare treatments and tests for those who use, manage and provide care in the NHS. It identifies the most important questions that the NHS needs the answers to by consulting widely with these groups, and commissions the research it thinks is most important through different funding routes. ![]()
Martin Burton
Director of the UK Cochrane Centre
2013 Martin Burton is Consultant Otolaryngologist at the Oxford Radcliffe NHS Trust, based at the John Radcliffe Hospital in Oxford. He is also Senior Clinical Lecturer at the University of Oxford and Lecturer in Clinical Medicine at Balliol College. He was the founding co-ordinating editor of the Cochrane Ear, Nose & Throat Disorders Group (www.cochrane-ent.org) and Clinical Lead of the ENT & Audiology Library of the UK’s National Library for Health. He is interested in teaching and was an examiner for the Royal College of Surgeons of England IMRCS and IDOHNS exams. He trained as a medical student at Cambridge and Oxford Universities and did his early clinical training in Oxford and Bristol. He was a Fulbright Scholar and undertook research training at the Kresge Hearing Research Institute at the University of Michigan. Following a period as Lecturer in Otolaryngology at the University of Melbourne, he completed his doctoral thesis on the safety of cochlear implantation in small children. His higher surgical training was completed in London and as Fellow in Otology, Neurotology & Skull Base Surgery at Johns Hopkins University in Baltimore, USA. His clinical practice is otological - particularly middle ear surgery, tinnitus and balance disorders. He is interested in the application of evidence- (and wisdom-) based medicine in Otolaryngology and in otolaryngological epistemology and heuristics. Director of the UK Cochrane Centre
all sessions
A2 Building blocks of healthcare guidance
Session: Key tools for decision makers - how to find and interpret systematic reviews
![]() Martin Burton Director of the UK Cochrane Centre 25th Mar 2013 - 11:20
Martin Burton is director of the UK Cochrane Centre which has special responsibility for Cochrane entities and contributors in the UK, Ireland and the Middle East. It has a Branch in Bahrain. Cochrane Centres help to maintain and improve the quality and usefulness of Cochrane reviews through the provision of learning, development and support to Cochrane entities. The center, under Martin’s direction, It has had an important role as a knowledge broker and is developing and implementing a key programme of engagement with UK stakeholders to reflect the very substantial overall support given by the UK Government, through the NIHR, to Cochrane activities. At the same time, it seeks to develop new engagement activities that will maximise the quality and relevance of Cochrane outputs to health and social care throughout the world. ![]()
Lesley Stewart
Director of Centre for Reviews and Dissemination (CRD)
2013 Lesley has been Director of CRD since 2006 and has been involved in evidence synthesis in healthcare since the late 1980's, previously running the MRC Clinical Trials Unit meta-analysis research programme. Together with colleagues in Cambridge and Oxford, she helped establish the methodology and framework for individual patient data (IPD) reviews. She was a founding member of the Cochrane Collaboration, co-convenes the Cochrane Collaboration IPD Meta-analysis Methods Group and is a member of the Collaboration Methods Board and the Handbook Editorial Advisory Panel. Recently, Lesley has also overseen and been actively involved in the development of an international prospective register of systematic reviews which CRD launched in February 2011. Director of Centre for Reviews and Dissemination (CRD)
all sessions
A2 Building blocks of healthcare guidance
Session: Building blocks of healthcare guidance:increasing access to trial data and systematic reviews of individual participant data.
![]() Lesley Stewart Director of Centre for Reviews and Dissemination (CRD) 25th Mar 2013 - 11:20
In addition to her role as Centre Director, Lesley maintains research interests in the conduct and methodological development of systematic reviews, particularly individual participant data (IPD) meta-analysis. She is currently principal investigator (PI) of a project funded by Yale University to carry out an IPD meta-analysis of a controversial product used in spinal surgery, including scrutiny and re-analysis of clinical trial IPD deposited with Yale by the manufacturer. She is also PI of a three year MRC funded project evaluating the utility of various approaches to IPD synthesis, and PhD supervisor of an IPD meta-analysis to identify the patterns of risk in febrile neutropenia. Lesley has also overseen and been actively involved in the development of PROSPERO, an international prospective register of systematic reviews which CRD launched in February 2011. Chaired by
David Tovey Editor in Chief, The Cochrane Library Chaired by David Tovey Editor in Chief, The Cochrane Library | A3 Public-patient involvement ![]()
Margaret McCartney
GP in Glasgow and author of the book The Patient Paradox
2013 Margaret McCartney is a GP in Glasgow who started writing for the press over a decade ago after a newspaper article insisted that a regular CT body scan was a great way to stay well. She has written for most broadsheets and is a regular contributor to the BMJ and Radio 4’s Inside Health. Her book ‘The Patient Paradox- why sexed up medicine is bad for your health’ was published in 2012. GP in Glasgow and author of the book The Patient Paradox
all sessions
A3 Public-patient involvement
Session: The Patient Paradox
![]() Margaret McCartney GP in Glasgow and author of the book The Patient Paradox 25th Mar 2013 - 11:20
Here's my problem. If I have a patient who is at high risk of premature death - say, who is a smoker, has heart disease, is under enormous economic stress, and who has a new diagnosis of depression; it will take three months, at least, for him to start evidence based cognitive treatments. This is if he can remember to fill in the right forms and get through on the phone to confirm he still wants it. Contrast this with a patient who is sent an appointment for breast screening, and is diagnosed and treated for ductal carcinoma in situ. My first patient needs to become a patient yet can't, and is inadequately treated; my female patient - who was initially quite well - probably isn't going to benefit from a diagnosis she was inadequately warned about, becomes a patient, and is likely overtreated. How can the public make sense of a system which often prioritises the wants of the well beyond the needs of the sick - and why have we failed to explain or change this unfairness? ![]()
Sally Crowe
Co Chair James Lind Alliance
2011 2013 Sally has a nursing and public health background. As director of Crowe Associates Ltd www.crowe-associates.co.uk , which provides consultancy, training and project management for patient and public involvement in health, she regularly facilitates workshops and consultation events in health and social care research, and services development in the UK and Europe. Teaching critical appraisal and understanding evidence skills to a wide range of people, continues to be a passion. She has recently published a BMJ Wiley Blackwell Patient and Public Involvement Toolkit. She chairs the James Lind Alliance Monitoring and Implementation Group (www.lindalliance.org), a national coalition that aims to tackle treatment uncertainties in health care. This is primarily achieved through Priority Setting Partnerships of patient and clinician groups, and Sally is currently working with partnerships in pressure ulcers, pre term birth, and multiple sclerosis. With this increasing interest and experience of prioritisation of research Sally has recently joined the Cochrane Collaboration as a co convenor of the Agenda and Priority Setting Methods Group. May 2012 Co Chair James Lind Alliance
all sessions
A3 Public-patient involvement
Session: Who holds the power in prioritising health care research….time for change?
![]() Sally Crowe Co Chair James Lind Alliance 25th Mar 2013 - 11:20
This presentation will focus on the dynamics and balance of power in processes for prioritising research. It will consider what patients, carers and the public (and clinicians) can contribute to research prioritisation, and how they can be involved meaningfully using the James Lind Alliance model of Priority Setting Partnerships as an example. As the James Lind Alliance prepares to move to the NIHR Evaluation, Trials and Studies Coordinating Centre (NETSCC) this presentation will reflect on the last 6 years experience of research priority setting in many disease areas, involving many different people. What has worked? What hasn’t? How important has the values base of the JLA and Priority Setting Partnerships model influenced the process, and has the balance of power really been redressed using this approach? ![]()
Martine Price
Head of Patient Experience, Taunton and Somerset NHS Foundation Trust
2013 Martine took up the post of Head of Patient Experience at Taunton and Somerset NHS Foundation Trust in November 2010. This was a new senior leadership role for the hospital designed to ensure visibility and momentum for a Trust wide patient experience programme. Head of Patient Experience, Taunton and Somerset NHS Foundation Trust
all sessions
A3 Public-patient involvement
Session: The role of patient experience in driving health care improvement and innovation
![]() Martine Price Head of Patient Experience, Taunton and Somerset NHS Foundation Trust 25th Mar 2013 - 11:20
Improvement often focuses on clinical systematic processes to improve outcomes. By involving patients and their families and using tried and tested interventions you improve both the processes and the patient experience of care. Patient experience is about putting the patient at the heart of quality improvement. This presentation gives an overview of Musgrove Park Hospital’s journey of improvement and how an Improvement Network led by clinicians at the front line is driving significant improvements in clinical outcomes, the experience of both patients and staff and at the same time driving efficiency. Chaired by
Sir Iain Chalmers James Lind Initiative, Oxford, UK Chaired by Sir Iain Chalmers James Lind Initiative, Oxford, UK | Workshop & Poster Sessions
all sessions
Workshop & Poster Sessions
Session: Oral Posters & Exhibitions
25th Mar 2013 - 11:20
Oral Poster SessionsThe East room will host Oral poster sessions and a poster gallery. Presenters will be sharing their research with a five minute presentation and two minute for Q & A, these presentations will be supported by the poster which will also be on display throughout the whole event. Workshop: How to Teach EBM  
all sessions
Workshop & Poster Sessions
Workshop: How to Teach EBM
25th Mar 2013 - 11:20
more details coming soon
Workshop: How to Appraise RCTs  
all sessions
Workshop & Poster Sessions
Workshop: How to Appraise RCTs
25th Mar 2013 - 11:20
more details coming soon
|
| 12:50 | Lunch | |||
| 13:50 | K4 Keynote: Evidence, policy and politics ![]()
Clare Gerada
Chair of Council of the RCGP
2013 Dr Clare Gerada has held a number of local and national leadership positions, including Director of Primary Care for the National Clinical Governance Team and Senior Medical Advisor to the Department of Health. She is Medical Director of the PHP Programme and has published a number of academic papers, articles, books and chapters. Dr Gerada has been a GP since 1992, when she became a partner for the Hurley Clinic in South London. The practice started life in 1969 – and remains on its current site – on the ground floor of a 19-storey housing estate in Lambeth. Chair of Council of the RCGP
all sessions
K4
Keynote: Evidence, policy and politics
![]() Clare Gerada Chair of Council of the RCGP 25th Mar 2013 - 13:50
One of modern medicine’s greatest strengths is its evidence base. It’s the jewel in our crown. Modern medicine – though far from perfect – has nevertheless flourished through the systematic application of rigorous, evidence-based research. I will be discussing how far evidence in the political arena compares to that used to manage patients and what this has meant for the delivery of our health care and the NHS | |||
| 14:20 | K5 ![]()
Prabhat Jha
Professor, Dalla Lana School of Public Health, University of Toronto
2013 Prabhat Jha is Canada research chair of health and development at the University of Toronto. He is also the founding director of the Centre for Global Health Research, St. Michael's Hospital; associate professor in the Department of Public Health Sciences, University of Toronto; research scholar at the McLaughlin Centre for Molecular Medicine; and professeur extraordinaire at the Université de Lausanne, Switzerland. Dr. Jha is lead author of Curbing the Epidemic: Governments and the Economics of Tobacco Control and co-editor of Tobacco Control in Developing Countries. Both are among the most influential books on tobacco control. He is the principal investigator of a prospective study of 1 million deaths in India, researching mortality from smoking, alcohol use, fertility patterns, indoor air pollution, and other risk factors among 2.3 million homes and 15 million people. This work is currently the world's largest prospective study of health. He also conducts studies of HIV transmission in various countries, focusing on documenting the risk factors for the spread of HIV and interventions to prevent the spread of the HIV/AIDS epidemic. His studies have received more than $5 million in peer-reviewed grants. Dr. Jha has published widely on tobacco, HIV/AIDS, and health of the global poor. His awards include a Gold medal from the Poland Health Promotion Foundation (2000), the Top 40 Canadians under Age 40 Award (2004), and the Ontario Premier's Research Excellence Award (2004). Dr. Jha was a research scholar at the University of Toronto and McMaster University in Canada. He holds an M.D. from the University of Manitoba and a D. Phil. in epidemiology and public health from Oxford University, where he studied as a Rhodes Scholar at Magdalen College. Professor, Dalla Lana School of Public Health, University of Toronto
all sessions
K5
Keynote: Counting the dead in developing countries
![]() Prabhat Jha Professor, Dalla Lana School of Public Health, University of Toronto 25th Mar 2013 - 14:20
Human life expectancy improved more in the last 50 years than in the preceding 5000 years. Much of this recent progress arose from declines in childhood mortality, and most of this decline was due to scientific knowledge and technologies (defined widely as drugs, diagnostics, policies, strategies, and epidemiological knowledge). The dominant challenge of the 21st century is to apply scientific knowledge to reduce premature adult mortality, in particular from vascular and neoplastic disease but also from persistent infectious disease such as malaria. Reliable quantification of the causes of death is a key starting point for control of adult diseases, as shown by the early results from India's Million Death Study. A key global priority is the control of tobacco use. Scientific research on adult mortality, paired with specific action, might well halve premature adult mortality worldwide in the next few decades. | |||
| 14:50 | K6 ![]()
Howard Bauchner
Editor-in-Chief of JAMA
2013 Howard Bauchner, M.D., is Editor-in-Chief of JAMA and the JAMA Network. He became the 16th editor of JAMA in July 2011. He completed his undergraduate training at the University of California, Berkeley (1974) and graduated from Boston University School of Medicine (1979). He completed his pediatric residency at Boston City and Yale-New Haven Hospitals (1979-1984) and was a Robert Wood Johnson Foundation Fellow in General Paediatrics at Yale (1984-1986). He joined the faculty at BUSM/BMC in 1986, was promoted to Associate Professor in 1990 and to Professor in 1997. He became a member of the society of Paediatric Research in 1996 and american Paediatric Society in 2001. Editor-in-Chief of JAMA
all sessions
K6
Keynote: Scientific integrity in scholarly research - the challenge for publishers
![]() Howard Bauchner Editor-in-Chief of JAMA 25th Mar 2013 - 14:50
It is challenging for editors and publishers to ensure that what they publish is valid. This issue is relevant for opinion pieces, reviews, and research regardless of authorship and funding. Over the past decade various approaches have been developed to ensure that results are valid – will any succeed? | |||
| 15:20 | Coffee & Guided Poster Sessions | |||
| 16:10 | B1 Medical Devices ![]()
Deb Cohen
Assistant Editor, BMJ
2011 2013 Deborah Cohen is investigations editor of the BMJ, which she joined after studying medicine at both Manchester University and Universite de Rennes. Whilst at university she intercalated in medical journalism, edited her university publication and worked on a newspaper in Ghana covering health and human rights. Deborah has reported from a variety of places including the West Bank, Kenya and Ethiopia. As investigations editor of the BMJ, much of her work has focused on drug and medical device regulation, access to clinical data and conflicts of interest. She has collaborated on documentaries with the BBC, Channel 4 News and Dispatches, and Al-Jazeera, as well has having working jointly with the Bureau of Investigative Journalism. Assistant Editor, BMJ
all sessions
B1 Medical Devices
Session: Investigating the evidence for medical devices
![]() Deb Cohen Assistant Editor, BMJ 25th Mar 2013 - 16:10
Deb Cohen is a medically qualified reporter and BMJ editor with an extensive international contacts book and a proven track record in hard hitting health and science investigations. As a reporter and commissioning editor of the BMJ, Deborah will talk about her work which has focused mainly on health including pharmaceuticals, genetics, nutrition, medical implants, pseud-scientific claims and food. As well as writing for print, she has co-produced documentaries and reported for Newsnight and been interviewed many times by the international media and explained complex subjects to a non-specialist audience following the publication of investigations. Peter McCulloch Clinical Reader in Surgery, University of Oxford
all sessions
B1 Medical Devices
Session: The IDEAL Collaboration: helping to improve research quality in surgery and other complex interventions
![]() Peter McCulloch Clinical Reader in Surgery, University of Oxford 25th Mar 2013 - 16:10
IDEAL is a descriptive framework for the stages of surgical innovation. The IDEAL Collaboration is working on ways to improve the reliability, relevance and fundability or research in surgery, medical devices and other areas of complex information. Why IDEAL? Because surgery is procedure-based, it presents challenges to gathering, reporting, and applying sound evidence that are not seen in medicine. These challenges are faced by everyone involved in producing and using evidence: researchers, journal editors, clinicians, device manufacturers, and regulators. What are the stages of surgical innovation as described by IDEAL? First, there is an Idea or Innovation, which then undergoes Development and Exploration, and subsequently Assessment and Long-term Studies). Within this framework are recommendations at each stage for methodology, reporting, and, where applicable, regulation. ![]()
Pauline McCormack
Research Associate, Newcastle University
2013 PauPauline McCormack is a research associate at Policy Ethics and Life Sciences (PEALS) research centre and has a background in education, social policy and participatory methods. She will present her research on the impact that the metal-on-metal hip fiasco has had on patients’ lives. Research Associate, Newcastle University
all sessions
B1 Medical Devices
Session: "Are patients just pound signs?": perspectives of people with failed metal on metal hip implants
![]() Pauline McCormack Research Associate, Newcastle University 25th Mar 2013 - 16:10
The ASR metal-on-metal (MoM) hip replacement manufactured by DePuy Orthopaedics (a subsidiary of Johnson & Johnson) and implanted into almost 100,000 people worldwide, has failed in unprecedented numbers. The implant is currently the subject of legal dispute worldwide. In focus groups that we conducted with MoM hip patients they asked “who knew what and when”? They recount lives disrupted and ruined by the health problems caused through having a faulty implant and the attendant anxiety about possible long-term, systemic health issues. This talk examines the response of UK stakeholders to the DePuy ASR hip implant failure and asks if, in order to prevent future occurrences, a more precautionary approach should be taken in light of data which indicates potential problems. We reflect on the patients’ most profound question, “could all this have been avoided”? Chaired by
Carl Heneghan Director, Centre for Evidence-Based Medicine, University of Oxford Chaired by Carl Heneghan Director, Centre for Evidence-Based Medicine, University of Oxford | B2 Diagnostics ![]()
Nick Crabb
Associate Director, Diagnostics Assessment Programme, NICE
2013 Nick had a 20 year career in analytical science, process technology and general management in the chemical, pharmaceutical and contract laboratory industries prior to joining NICE as the associate director for the new Diagnostics Assessment Programme (DAP) in January 2010. The DAP is a specialist programme at NICE to evaluate the clinical and cost effectiveness of innovative medical diagnostic technologies leading to guidance on their adoption to the NHS in England. Nick is responsible for the on-going management and development of the programme and also leads on NICE's activities to develop methods and processes for evaluating companion diagnostics across its pharmaceutical and diagnostic evaluation programmes. Associate Director, Diagnostics Assessment Programme, NICE
all sessions
B2 Diagnostics
Session: The Challenges of Evidence-Based Diagnostics: A NICE Perspective
![]() Nick Crabb Associate Director, Diagnostics Assessment Programme, NICE 25th Mar 2013 - 16:10
The presentation will briefly introduce the programmes at NICE where diagnostic technologies are evaluated. In the NICE diagnostics assessment programme, and in clinical guidelines, cost effectiveness methodology is deployed. In the NICE medical technologies evaluation programme, a simpler cost consequences methodology is adopted. Some of the general challenges of diagnostics assessment will then be presented before moving on to evidence considerations. Examples from published NICE guidance will also be given to illustrate both the cost effectiveness and cost consequences methodologies. The presentation will conclude with consideration of forward priorities for the further development of evidence based diagnostics. ![]()
Paul Glasziou
Professor, Centre for Research in Evidence-Based Practice, Bond University, Australia.
2010 2013 Professor Paul Glasziou was previously the Director of the Centre for Evidence-Based Medicine, and Professor of Evidence-Based Medicine in the department of Primary Care at the University of Oxford, and also continues work as a part-time General Practitioner. The author of over 150 peer-reviewed publications, in medical decision making, clinical trials, systematic reviews and evidence-based medicine. He was editor of the BMJs journal of Evidence-Based Medicine for 10 years. He is a member of the management committee of the 3 largest clinical trials ever conducted in Australia: the LIPID, FIELD, and ADVANCE studies. He has published 6 books on evidence-based health care and decision making: Systematic Reviews in Health Care, Decision Making in Health Care and Medicine: integrating evidence and values, An Evidence-Based Medicine Workbook, Clinical Thinking: Evidence, Communication and Decision-making, Evidence-Based Medicine: How to Practice and Teach EBM, and Evidence-Based Medical Monitoring: Principles and Practice. In 2009 he was awarded an NHMRC Australia Fellowship, and will move back to Australia. Professor, Centre for Research in Evidence-Based Practice, Bond University, Australia.
all sessions
B2 Diagnostics
Session: Evidence-Based Monitoring: Which test? How often?
![]() Paul Glasziou Professor, Centre for Research in Evidence-Based Practice, Bond University, Australia. 25th Mar 2013 - 16:10
Monitoring and management of long term illness is an important and costly element of health care It accounts for around 80% of GP consultations, and a substantial proportion of laboratory testing. Despite the high workload and costs, monitoring has been neglected as an area for research and guidance. And the little evidence that we have has not been widely applied. For example, despite clear evidence that daily glucose monitoring is not warranted in type 2 diabetes, the global costs of glucose monitoring strips alone exceed $1Billion per year. The clinical monitoring for several other conditions - including lipid management, blood pressure management, telemonitoring and HbA1c testing - do not align with the current evidence. However, optimal monitoring requires identify the best monitoring test, an appropriate schedule, and the optimal adjustments for out-of-range measurements. Current randomised trials of monitoring showed a mixed pattern of effects, but few appear to have optimized monitoring protocols prior to the trial. Jon Deeks Professor of Biostatistics, University of Birmingham
all sessions
B2 Diagnostics
Session: Why are systematic reviews of diagnostic tests needed but so complicated?
![]() Jon Deeks Professor of Biostatistics, University of Birmingham 25th Mar 2013 - 16:10
Evaluations of diagnostic tests need to consider a) how tests impact on patients, b) their role and position in clinical pathways, c) the alternatives with which they must be compared. In this presentation we will consider how systematic reviews of test accuracy are a necessary part of a test evaluation but not always sufficient to predict the impact of a test on patients, when it is important to assess other aspects of test performance, and how our ability to evaluate test accuracy is hindered by poor and inadequate primary research. Key references:
Chaired by
Patrick M.M. Bossuyt Professor of Clinical Epidemiology, University of Amsterdam Chaired by Patrick M.M. Bossuyt Professor of Clinical Epidemiology, University of Amsterdam | B3 Evidence in low-income settings ![]()
Khamis Elessi
Head of the Gaza Evidence-Based Medicine Unit, Islamic University
2013 Khamis A. Elessi MSc, MD, Palestinian Board in PM&R. He had his medical education and clinical training in various countries (phillipines, Israel and the UK) with two years in Bristish hospitals. He has chaired the medical rehab team at Elwafa Med Rehab Hospital in Gaza for the last 15 years and mainly worked in the field of Neuro-Rehabilitation and Pain Management. Now he is full time Assistant Professor at the college of medicine in the Islamic University-Gaza where he founded the first Palastinian EBM unit to promote EBM throughout Gaza Strip. Head of the Gaza Evidence-Based Medicine Unit, Islamic University
all sessions
B3 Evidence in low-income settings
Session: Challenges delivering evidence-based practice in conflict zones
![]() Khamis Elessi Head of the Gaza Evidence-Based Medicine Unit, Islamic University 25th Mar 2013 - 16:10
The overall goal of my talk is to provide you with the most important health indicators in Palestine, particularly the Gaza Strip. I’ll shed some light on key aspects of medical education in Gaza, including the medical schools, their curricula, languages, and facilities available to students, such as medical libraries and journals. Characteristics of doctors such as their education, place of graduation and some quality issues will be discussed. Finally, I will talk about the establishment of the first EBM unit in Palestine at the IUG, the context in which it is evolving, its accomplishments to date, plans for the future and the challenges we face. ![]()
Catherine Gallagher
Director, Cochrane Collaboration College for Policy
2013 Catherine Gallagher, PhD is a professor and Director of the Cochrane Collaboration College for Policy at George Mason University, just outside of Washington, D.C. The mission of the Cochrane Policy College is to provide policy-makers with rigorous evidence as they broach health and social policy decisions and appropriations. She has appeared numerous times before the US Congress and on televised policy interviews, providing commentary on the rigor of evidence behind current decision-making. She serves on the Cochrane Fields Executive, is the founder and Director of Cochrane’s Justice Health Field, and is currently an appointee to boards serving the Institute of Medicine and the Secretary of Health and Human Services. Her team is among the founding members of the Cochrane Response Consortium – a group of Cochrane contributors dedicated to exploring rapid evidence synthesis methods. Director, Cochrane Collaboration College for Policy
all sessions
B3 Evidence in low-income settings
Session: Cochrane and policy
![]() Catherine Gallagher Director, Cochrane Collaboration College for Policy 25th Mar 2013 - 16:10
Catherine is Director of the Cochrane Collaboration College for Policy at George Mason University, just outside of Washington, D.C. The mission of the Cochrane Policy College is to provide policy-makers with rigorous evidence as they broach health and social policy decisions and appropriations. ![]()
Kathryn Maitland
Professor, KEMRI-Wellcome Trust Research Programme
2013 Prof maitland specialises in paediatric infectious disease, critical care and international child health. She leads a research group in East Africa whose major research portfolio includessevere malaria, bacterial sepsis and severe malnutrition. her group has recently completed the largest trial of criticall ill children ever taken in Africa (FEAST Trial) examining fluid resusitation strategies in children with severe febrile illness which is likely to lead to major changes in health policy in children with severe illness in sub-Saharan Africa. her next trial (TRACT) will include 4000 children admitted to hospital with severe and life threatening anaemia and will examin transfusion and treatment strategies to improve the shot- and long-term outcome. Professor, KEMRI-Wellcome Trust Research Programme
all sessions
B3 Evidence in low-income settings
Session: High quality randomised controlled trials in fluid resuscitation sub-saharan Africa: it is possible?
![]() Professor Kathryn Maitland Professor, KEMRI-Wellcome Trust Research Programme 25th Mar 2013 - 16:10
FEAST, a controlled trial of fluid resuscitation, in children aged >60 days with severe febrile illness showed that early rapid fluid resuscitation (boluses) increased absolute 48-hour mortality by 3.3% versus controls (no bolus). The results, published in NEJM last year, challenged the primacy of bolus resuscitation as a life-saving intervention in resource-limited settings, and also raised questions on fluid resuscitation elsewhere. My talk will cover the background to the FEAST trial, work leading up, results and subsequent response to it publication. In addition, further analysis on putative modes of death, according to terminal clinical events. Chaired by
Ginny Barbour Chief Editor, PLoS Medicine Chaired by Ginny Barbour Chief Editor, PLoS Medicine | Workshop & Poster Sessions
all sessions
Workshop & Poster Sessions
Session: Oral & Guided Poster Sessions
25th Mar 2013 - 16:10
Oral Poster SessionsThe East room will host Oral poster sessions and a poster gallery. Presenters will be sharing their research with a five minute presentation and two minute for Q & A, these presentations will be supported by the poster which will also be on display throughout the whole event. Guided Poster Sessions... continued from Coffee break Guided poster sessions will run during break times. Posters will be grouped by area of interest, where authors will be taken through a session by a leading expert in the field allowing each two minutes to share their research project. Workshop: How to Use Social Media
all sessions
Workshop & Poster Sessions
Workshop: How to Use Social Media
25th Mar 2013 - 16:10
More details coming soon
Workshop: How to Get Published
all sessions
Workshop & Poster Sessions
Workshop: How to Get Published
25th Mar 2013 - 16:10
More details coming soon
|
| 17:30 | K7 ![]()
Michael Rawlins
Chairman of the National Institute of Health & Clinical Excellence (NICE)
2013 Sir Michael Rawlins has been chairman of the National Institute of Health & Clinical Excellence (NICE) since its formation in 1999. He is also an Honorary Professor at the London School of Hygiene and Tropical Medicine, University of London, and Emeritus Professor at the University of Newcastle upon Tyne. He was the Ruth and Lionel Jacobson Professor of Clinical Pharmacology at the University of Newcastle upon Tyne from 1973 to 2006. At the same time he held the position of consultant physician and consultant clinical pharmacologist to the Newcastle Hospitals NHS Trust. He was vice-chairman (1987-1992) and chairman (1993-1998) of the Committee on Safety of Medicines; and chairman of the Advisory Council on the Misuse of Drugs (1998 - 2008). He is President of the Royal Society of Medicine. Chairman of the National Institute of Health & Clinical Excellence (NICE)
all sessions
K7
Keynote: Saints or Sinners - what is the role of the pharmaceutical industry?
![]() Sir Michael Rawlins Chairman of the National Institute of Health & Clinical Excellence (NICE) 25th Mar 2013 - 17:30
Sir Michael Rawlins recently stepped down as chairman of the National Institute of Health & Clinical Excellence (NICE), having been at its helm since its formation in 1999. He has a wealth o f experience and was appointed Knight Bachelor in 1999 for services to the improvement of patient protection from the side effects of medicinal drugs. He is the current President of the Royal Society of Medicine. | |||
| 18:00 | Close | |||
| 19:00 | - - - NEW TO EVIDENCE 2013 - - - Queens College Hall, Oxford University
| |||
| Evidence Live 2013 - Tuesday 26th March | ||||
| 08:00 | Registration | |||
| 09:00 | Introduction: Opening Presentation ![]()
Ben Goldacre
Award-winning writer, broadcaster & medical doctor. Author of weekly Guardian column and book: 'Bad Science'
2010 2011 2013 Ben is an award-winning writer, broadcaster, and medical doctor who specialises in unpicking dodgy scientific claims made by scaremongering journalists, dodgy government reports, evil pharmaceutical corporations, PR companies and quacks. He has written the weekly Bad Science column in the Guardian since 2003. It’s archived on this site along with blogposts, columns for the British Medical Journal, and other stuff. “Bad Science” the book (4th Estate) has sold 240,000 copies, reached #1 in the paperback non-fiction charts, and is being published in 18 countries. Ben has won various awards, including the Royal Statistical Society’s first Award For Statistical Excellence in Journalism, shortlisted in the Samuel Johnson and Royal Society literary prizes 2009, the Faculty of Public Health DARE Prize Lecture, an honorary doctorate from Herriott-Watt University, “Best Freelancer” at the Medical Journalists Awards 2006, the Healthwatch Award in 2006, “Best Feature” at the British Science Writers Awards twice, and a few other bits and pieces. Award-winning writer, broadcaster & medical doctor. Author of weekly Guardian column and book: 'Bad Science' | |||
| 09:20 | K8 ![]()
John E. "Jack" Wennberg
Director of Clinical Evaluative Clinical Sciences (CECS), Dartmouth Medical School
2013 John E. Wennberg, M.D., M.P.H., is the Peggy Y. Thomson Professor (Chair) in the Evaluative Clinical Sciences and Founder and Director Emeritus of The Dartmouth Institute for Health Policy and Clinical Practice. He has been a Professor in the Department of Community and Family Medicine since 1980 and in the Department of Medicine since 1989. With colleague Alan Gittelsohn, Dr. Wennberg developed a method of determining population-based rates for the utilization and distribution of health-care services. This method, called small area analysis and first published in 1973, revealed large variations in health care usage among different areas. Work to uncover the reasons behind these variations led Wennberg and his colleagues to develop techniques to document the results of common medical practices, a strategy that came to be called outcomes research. Dr. Wennberg is the founding editor of The Dartmouth Atlas of Health Care, which examines the patterns of medical resource intensity and utilization in the United States. The Atlas project has also reported on patterns of end of life care, inequities in the Medicare reimbursement system, and the underuse of preventive care. Dr. Wennberg and colleague Al Mulley are co-founders of the Foundation for Informed Medical Decision Making, a non-profit corporation providing objective scientific information to patients about their treatment choices using interactive media. His latest work has focused on the use of this technology to inform patients of the results of outcomes research so they can participate in medical decision making. Director of Clinical Evaluative Clinical Sciences (CECS), Dartmouth Medical School
all sessions
K8
Keynote: Addressing unwarranted variation in healthcare - can better care cost less?
![]() John E. "Jack" Wennberg Director of Clinical Evaluative Clinical Sciences (CECS), Dartmouth Medical School 26th Mar 2013 - 09:20
Medical practice occurs within a local context. Per capita expenditures, resource use and utilization rates vary extensively among regions, communities and health care organizations, and raise serious policy questions concerning the effectiveness and efficiency of health care delivery. Much of the variation is unwarranted: It isn’t explained by illness, evidence-based medicine or patient preferences. Variation leads naturally to a question: Can better care cost less? Examples of research discussed in this lecture provide benchmarks that suggest the answer is Yes! But to reduce variation and realize savings of a magnitude that seems possible, it will take a concerted effort to address the weaknesses in the scientific and ethical basis of clinical decision making uncovered by variation research. | |||
| 09:40 | K9 Keynote: Issues in conducting overviews – tensions between avoiding bias and understanding the context ![]()
Jack Cuzick
Professor of Epidemiology, Wolfson Institute of Preventive Medicine
2013 Professor Cuzick is a leading epidemiologist working on screening and prevention of cancer. He is internationally recognised for having played a major role in developing the field of chemoprevention of breast cancer. In 1985 he made the seminal observation that, in addition to reducing the recurrence rate of breast cancer in women being treated for breast cancer, tamoxifen can also prevent the occurrence of new contralateral tumours. He has made valuable contributions to assessing the risk of developing breast cancer. Professor Cuzick has also made key contributions to cancer screening, with his work leading to major reorganisation of UK screening programmes in the NHS. Professor of Epidemiology, Wolfson Institute of Preventive Medicine
all sessions
K9
Keynote: Issues in conducting overviews – tensions between avoiding bias and understanding the context
![]() Jack Cuzick Professor of Epidemiology, Wolfson Institute of Preventive Medicine 26th Mar 2013 - 09:40
In analysing data a balance needs to be struck between general statistical principles and an understanding of the subject matter. Of late more and more prescriptive requirements are being drawn up as to how different sorts of studies should be presented. For overviews the PRISMA checklist of 27 items is now the standard and for RCTs the 25 item CONSORT checklist is used. While helpful in general, these checklists are no replacement for a good understanding the subject matter of the overview and judgement about the quality of the studies which often has a subjective component. In this lecture this tension is explored and some examples are given where the blind following of prespecified rules has led to reviews which defy common sense. | |||
| 10:10 | K10 ![]()
Peter Wilmshurst
Honorary Consultant Cardiologist, University Hospital of North Staffordshire
2013 Dr Peter Wilmshurst, a cardiologist at University Hospital of North Staffordshire, has spent the last two decades trying to expose research misconduct and has reported more than twenty doctors to the General Medical Council. In recognition of his dogged and selfless pursuit of the truth, Dr Wilmshurst was presented with the HealthWatch Award 2003. Honorary Consultant Cardiologist, University Hospital of North Staffordshire
all sessions
K10
Keynote: Research misconduct in pharmaceutical and medical devices industries
![]() Peter Wilmshurst Honorary Consultant Cardiologist, University Hospital of North Staffordshire 26th Mar 2013 - 10:10
Critical steps in Evidence Based Medicine are systematic retrieval and critical analysis of the best available evidence. Greater value is given to randomised controlled trials and meta-analysis than to case studies. This talk will discuss personal experience and case studies showing industry’s use of bribes and legal tactics, including gagging contracts and libel actions, to prevent publication of unfavourable results; and the role of undisclosed conflicts in the misreporting of research. From analysis of case studies showing widespread organisational and individual research misconduct it is concluded that in the era of Evidence Based Medicine much of the “higher quality evidence” cannot be trusted. | |||
| 10:40 | Coffee | |||
| 11:10 | C1 Modelling in healthcare ![]()
Ken Stein
Professor of Public Health, University of Exeter
2013 Ken Stein graduated in medicine from Bristol University, then trained and worked as a general practitioner in Australia and Hampshire before specialising in public health medicine in Southampton, where he subsequently became Deputy Director, NETSCC, HTA. In 1999 he moved to Exeter where he took up the position of Consultant in Public Health Medicine at North and East Devon Health Authority, then Director of Public Health for Mid Devon Primary Care Trust. Ken combined this NHS work with academic work at the University of Exeter as Director of the Peninsula Technology Assessment Group (PenTAG), before becoming a full time academic public health physician at the Peninsula College of Medicine and Dentistry in Exeter in 2003. He was appointed to a Chair in Public Health in 2007 and is now also Deputy Director of the Peninsula Collaboration for Leadership in Applied Health Research and Care (PenCLAHRC). His research interests include the use of quality of life estimates in health technology assessment, synthesis of qualitative research, and the use of decision analytic modelling to support planning and management in the NHS. Professor of Public Health, University of Exeter
all sessions
C1 Modelling in healthcare
Session: How modelling in health care influences decision making: the bottom line
![]() Ken Stein Professor of Public Health, University of Exeter 26th Mar 2013 - 11:10
Want to know how quality of life estimates in health technology assessment, synthesis of qualitative research, and the use of decision analytic modelling support planning and management in the NHS. ![]()
Steve Humphries
BHF Professor of Cardiovascular Genetics, University College London
2013 Steve Humphries is a worl-renowned expert in cardiovascular genetics, a field in which he has worked for over 30 years. After graduating from sussex university, he obtained his PhD in Biochemistry in Glasgow in 1974. following three years postdoctoral ork in the USA he worked in both St Mary's and charing Cross Hospitals in London, before moving to UCL in 1991. He is currently the British Heart Foundation Professor of Cardiovascular Genetics at the Royal Free and university College School of Medicine, London, where he heads a group of more than 30 scientists, students and technicians. current work includes the study of genes involved in lipid metabolism, inflamation, coagulation and fibrinolysis, and with genes expressed in cells of the artery wall. Much of his work has been in applying genetics in population-based studies, thus bridging genetics and epidemiology. current work focuses on the identification of the molecular mechanisms of the effects of gene variants and the use of the genetic tests to identify at-risk individuals, specifically those at risk of premature heart disease. BHF Professor of Cardiovascular Genetics, University College London
all sessions
C1 Modelling in healthcare
Session: When favourable economics doesn’t lead to implementation : Cascade Testing for Familial Hypercholesterolaemia an example
![]() Steve Humphries BHF Professor of Cardiovascular Genetics, University College London 26th Mar 2013 - 11:10
In the NICE Familial Hypercholesterolaemia (FH) guidelines CG71 published in August 2008, Cascade Testing was strongly recommended using DNA mutation information where it was available, or by determining levels of LDL-cholesterol in families where it was not. The NICE recommendations were based on evidence from extensive experience of Cascade Testing in Holland and in the UK, demonstrating the feasibility, acceptability and cost effectiveness of the approach, as well as modelling based on the available UK data which estimated the cost per quality adjusted life year gained is £2,111. Disappointingly, the 2010 RCP UK-wide audit of the management of FH in 118 lipid clinics (2471 patient notes) found that while Cascade Testing had been initiated in almost 75% of the notes examined, less than half of the proband’s children and less than 40% of their siblings had been contacted. DNA testing was only widely available in Wales, Scotland and Northern Ireland, highlighting the lack of funding under current commissioning arrangements. The data suggests that to be most effective, Cascade Testing requires education of commissioners and GPs, the establishment of specific FH clinics, and the setting up of a nationwide database to ensure effective linking of distant families. ![]()
Klim McPherson
Visiting Professor of Public Health Epidemiology
2013 Klim Mcpherson is a visiting professor of public health epidemiology at Oxford University and Fellow of New College. He chairs the National Heart Forum, concerned to prevent premature mortality from cardiovascular disease. His research is in epidemiology methods and women's health. Visiting Professor of Public Health Epidemiology
all sessions
C1 Modelling in healthcare
Session: The role of modelling in health care
![]() Klim McPherson Visiting Professor of Public Health Epidemiology 26th Mar 2013 - 11:10
While risk factor prevalences vary and change with time it is difficult to anticipate the change in disease that will result without accurately modelling the epidemiology. When detailed study of the prevalence of obesity, tobacco and salt intake, for example, are studied clear patterns emerge that can be extrapolated into the future. These can give rise to probability distributions of these risk factors across age, sex, ethnicity, social class groups etc into the future. Micro simulation of individuals from defined populations (eg England 2012) can then estimate disease incidence, prevalence, death and quality of life. Thus future health and other needs can be estimated and interventions on these risk factors can be simulated for their population effect. Thus health policy can be better determined by a realistic characterisation of public health. The Foresight microsimulation modelling of the National Heart Forum (UK Health Forum) will be described. Chaired by
Tobias Kurth Director of Research, INSERM Chaired by Tobias Kurth Director of Research, INSERM | C2 Latest in publishing ![]()
David Tovey
Editor in Chief, The Cochrane Library
2013 David Tovey has been the Editor in Chief of The Cochrane Library since January 2009. He worked previously as Editorial Director for the BMJ Evidence Centre, which is the division of the BMJ Group that produces Clinical Evidence and its counterpart for the public BestTreatments, BMJ Point of Care and Best Practice. Until 2003 David worked as a General Practitioner in an urban practice in South London for 15 years. During that time he also undertook roles in continuing professional development for primary care professionals and was a clinical governance lead for a Primary Care Group. Editor in Chief, The Cochrane Library
all sessions
C2 Latest in publishing
Session: Update from the Cochrane Collaboration: what's new, and what it will look like in 10 years?
![]() David Tovey Editor in Chief, The Cochrane Library 26th Mar 2013 - 11:10
Despite the increasing strategic importance of evidence in medicine, the future of publishing has probably never looked so uncertain. The inexorable progress of open access should mean that within a few years most journals will not sit behind pay walls, opening up evidence to everyone. We will see increasing innovation in terms of technology capabilities, with new tech start-ups challenging traditional publishers as they seek to bring knowledge to readers in different and more accessible ways. We will see an expansion in data availability with research being made available in open access databases and repositories and the growth of secondary research based on these data. We might even see the end of data being hidden by trial sponsors so that we can all achieve a more realistic understanding of the effects of healthcare interventions. All this is what we can anticipate, but there will be innovations and changes that seem unimaginable today. I aim to explore some of the possibilities and how this might change clinical practice, evidence synthesis and the development of guidelines. ![]()
Trish Groves
Deputy Editor, BMJ and Editor in Chief, BMJ Open
2011 2013 I have worked at the BMJ (British Medical Journal, bmj.com) for more than 20 years. I am one of three deputy editors and am also senior research editor. I lead the BMJ team that peer reviews and publishes original research articles, and also lead our international outreach programme, with key responsibility for helping researchers to maximise their chances of publication and for encouraging authors to send the BMJ their research. I write and maintain the BMJ’s editorial policies and instructions to authors, and have co-developed the BMJ’s regular workshops on peer review training. On behalf of the BMJ I have been a member of several research-related organisations and groups: the council of the Committee on Publication Ethics (2008-10), the CONSORT 2010 group on reporting randomised controlled trials, and the SPIRIT group on reporting trial protocols. I am also participating in strategic efforts to encourage the sharing of raw research data, to develop prognosis research methods, to revise the EU clinical trials directive, and to improve the practice of grant review. I helped to develop BMJ Open - the online-only open access general medical journal launched by BMJ Group in early 2011 (bmjopen.bmj.com) – and am its Editor in chief. BMJ Open is dedicated to publishing medical research from all disciplines and therapeutic areas and considers all research study types, from study protocols to phase I trials to meta-analyses, including small or potentially low-impact studies. Before joining the BMJ I trained in medicine at London’s Royal Free Hospital School of Medicine and then specialised in psychiatry, gaining MRCPsych in 1989. In 1998 I was an honorary research fellow at the School for Public Policy, University College London. I have presented programmes and series for BBC World Service radio, presented TVam’s Doc Spot, co-authored the HarperCollins Consumer Guide to Mental Health (winner of the Medical Journalists' Association best book of 1995), and edited the BMJ book Countdown to Community Care (1993). Deputy Editor, BMJ and Editor in Chief, BMJ Open
all sessions
C2 Latest in publishing
Session: Delivering open access publishing: lessons learnt from BMJ Open
![]() Trish Groves Deputy Editor, BMJ and Editor in Chief, BMJ Open 26th Mar 2013 - 11:10
BMJ Open is an online-only general medical journal. Along with providing completely open peer review and open access to all articles, BMJ Open is helping authors to deposit the raw data from their studies. How does this work? Why aren't other journals doing this? Who's sharing data? And what are the pros and cons of data sharing in research that involves real patients? ![]()
Ginny Barbour
Chief Editor, PLoS Medicine
2013 Ginny Barbour joined PLoS in 2004 and was one of the founding co-editors of PLoS Medicine; she was appointed the journal’s first Chief Editor in 2008. Her background in publishing comes from The Lancet. She studied Natural Sciences at Cambridge University, and then medicine at UCL and Middlesex Hospital School of Medicine, London. Her specialist clinical medical training was in Haematology at the Royal Free Hospital, London. She was awarded a DPhil from Oxford University in 1997 for research into globin gene regulation. Her post-doctoral work was at St. Jude Children’s Research Hospital in Memphis, Tennessee. She is the Secretary of the Committee on Publication Ethics, and is a member of the Ethics Committee for the World Association of Medical Editors. She has participated in discussions on a number of guidelines in publishing, including revisions to the CONSORT statement, and the development of the PRISMA statement. Her interests in publishing include not only open-access, but also the more rigorous reporting of research and the importance of taking an evidence-based approach to the priorities of global health. Chief Editor, PLoS Medicine
all sessions
C2 Latest in publishing
Session: What are the new possibilities in publishing that can emerge from the PLOS model?
![]() Ginny Barbour Chief Editor, PLoS Medicine 26th Mar 2013 - 11:10
The advent of the internet is enabling scientific and medical publishing to change radically. Not only has the liberation from a print-based medium allowed a change in how journals are accessed (and by whom) and the development of new business models for publishing, but in addition the use of licenses developed by Creative Commons is enabling innovative ways of reusing content. In addition, the change from journal-based metrics to article-based metrics is catalysing a change in assessment and understanding of the impact of research. Chaired by
Howard Bauchner Editor-in-Chief of JAMA Chaired by Howard Bauchner Editor-in-Chief of JAMA | C3 Best research papers of all time Chaired by Helen MacDonald, Editor of Student BMJ | Workshop & Poster Sessions
all sessions
Workshop & Poster Sessions
Session: Oral Posters & Exhibitions
26th Mar 2013 - 11:10
Oral Poster SessionsThe East room will host Oral poster sessions and a poster gallery. Presenters will be sharing their research with a five minute presentation and two minute for Q & A, these presentations will be supported by the poster which will also be on display throughout the whole event. Workshop: How to Use Social Media
all sessions
Workshop & Poster Sessions
Workshop: How to Use Social Media
26th Mar 2013 - 11:10
more details coming soon
Workshop: How to Peer Review
all sessions
Workshop & Poster Sessions
Workshop: How to Peer Review
26th Mar 2013 - 11:10
more details coming soon
|
| 12:30 | Lunch | |||
| 13:30 | K11 Keynote: How can EBM become successful? ![]()
Brian Haynes
Editor, ACP Journal Club
2013 I am a clinical epidemiologist/internist with experience in clinical care, clinical informatics and health services research in general, and practitioner performance and patient adherence in particular. My research activities fall in the domain of knowledge translation research, at the interface between health care research and clinical practice. I am particularly interested in creating evidence-based information services and systems to support evidence-informed health care decisions. Editor, ACP Journal Club
all sessions
K11
Keynote: How can EBM become successful?
![]() Brian Haynes Editor, ACP Journal Club 26th Mar 2013 - 13:30
In an ideal world, sound evidence from research would be enough to change clinical practice and patient-important outcomes. In real life, we need to shepherd evidence through information retrieval and appraisal processes, systematic reviews, guidelines, health care policy and resource allocation decisions, training programs, incentives and disincentives. The infrastructure to support most of these steps is increasingly robust and includes knowledge refineries, more efficient systematic reviews, higher quality guideline processes, more timely health policy initiatives, and the emergence of effective computerized point-of-care decision support. Clinician compliance and patient adherence remain major barriers to success and there are many opportunities for trailblazers and innovators. | |||
| 14:00 | K12 ![]()
Mike Kelly
Director of the Centre of Public Health Excellence, NICE
2011 2013 Professor Mike Kelly is Director of the Centre of Public Health Excellence at NICE. Director of the Centre of Public Health Excellence, NICE
all sessions
K12
Keynote: Developing evidence based public health - NICE and easy?
![]() Mike Kelly Director of the Centre of Public Health Excellence, NICE 26th Mar 2013 - 14:00
In 2005 NICE acquired the responsibility for the production of public health guidance on cost effective interventions to prevent disease and promote good health. The guidance was for the NHS and the wider public health community. The ambition was to build on the platform of evidence based medicine, and the experience NICE had acquired in the preparation of clinical guidelines and conducting health technology assessments. From the outset it was acknowledged that applying the principles of evidence based medicine to public health would require the methods and processes to be developed and to be allowed to evolve. This paper describes the scientific, methodological and practical challenges that have arisen in developing guidance in this way. Among other things the nature of the evidence base, the dynamics involved in complex public health interventions and the challenges presented by health inequalities, will be discussed. The problems associated with the strong emphasis on internal validity in evidence based medicine and the importance of external validity in public health will be explored. In conclusion, the significance of the judgement process in involved in interpreting the evidence will be considered. | |||
| 14:30 | Coffee & Guided Poster Sessions | |||
| 15:00 | D1 Evidence aid ![]()
Les Roberts
Director, Program on Forced Migration and Health
2013 Les Roberts holds a Ph.D. in Environmental Engineering and did a post-doctorate fellowship in epidemiology at the Centre for Disease Control and afterwards worked for WHO in Rwanda during the 1994 civil war and then for the international Rescue Committee. Les had led over 50 surveys in 17 countries, mostly measuring mortality in times of war. In recent years he has taken part in studies to measure mortality in Democratic Republic of Congo, Iraq, Zimbabwe and Central African Republic. His present research focuses on developing methods to document human rights violations, and on statistically representative surveillance methodologies. Director, Program on Forced Migration and Health
all sessions
D1 Evidence aid
Session: The lack of an evidence base for humanitarian interventions
![]() Les Roberts Director, Program on Forced Migration and Health 26th Mar 2013 - 15:00
The relief community attributes great success to the growing international humanitarian efforts associated with most disasters and prolonged humanitarian crises. Indeed, the frequency of very high mortality events, and the number of protracted conflicts has diminished since the end of the cold war. Certain elements of humanitarian relief, such as measles immunization appear to have contributed to the positive trends. Yet, many established guidelines and practices appear to have no published evidence base and few trials of any kind have been conducted in crisis situations. Pressure from funders, short funding cycles, and the melding of political and humanitarian agendas all conspire to undermine accountability efforts within the relief community. A review of the evidence base for the SPHERE Standards and some examples of counter-intuitive evaluation findings will be presented. ![]()
Paul Spiegel
Deputy Director of the Division of Programme Support and Management at the United Nations High Commissioner for Refugees (UNHCR)
2013 Dr Spiegel is the Deputy Director of the Division of Programme Support and Management at the United Nations High Commissioner for Refugees (UNHCR) as well as a Senior Fellow for the Harvard Humanitarian Initiative and Adjunct Professor at Johns Hopkins and Emory Schools of Public Health. He was previously Chief of the Public Health and HIV Section at UNHCR. Before UNHCR, Dr Spiegel worked as a Medical Epidemiologist in the International Emergency and Refugee Health Branch at the Centers for Disease Control and Prevention (CDC). Previously he worked as a medical coordinator with Médecins Sans Frontiéres and Médecins du Monde in refugee camps in Kenya and DRC as well as a consultant for numerous organisations including the Canadian Red Cross and the Pan American Health Organisation. Dr Spiegel's research interests in humanitarian emergencies are in HIV, epidemiological methods, and health information systems. He has published extensively in the field of humanitarian emergencies. He has won numerous awards including CDC's Charles C Shepard award for outstanding research in Assessment and Epidemiology. Deputy Director of the Division of Programme Support and Management at the United Nations High Commissioner for Refugees (UNHCR)
all sessions
D1 Evidence aid
Session: Innovative methods to gather health care access, cost and data quality in humanitarian emergencies
![]() Paul Spiegel Deputy Director of the Division of Programme Support and Management at the United Nations High Commissioner for Refugees (UNHCR) 26th Mar 2013 - 15:00
Much of the evidence for humanitarian response comes from refugee camps in low income countries. However, during the past few decades, more and more humanitarian crises are occurring in non-camp settings in middle income countries (e.g. the current Syrian crisis). Two examples of innovative methods to measure access and quality of care in these settings will be presented-balance score card for primary health care clinics and prospective surveillance for health care access and costs. Finally, the web-based “Twine” information system” will be presented to show the possibilities of sharing information to make decisions at the field level as well as advocacy for funding at the global level. ![]()
Bonnix Kayabu
Evidence Aid Co-ordinator at the Centre for Global Health
2013 Dr. Bonnix Kayabu is currently enrolled in the International Doctorate School in Global Health (INDIGO) at Trinity College Dublin. He is focusing on the potential role of systematic reviews in humanitarian emergencies. Bonnix has been coordinating the Evidence Aid project since 2010. As part of this work he has met many key aid workers and conducted a needs assessment survey to identify their attitudes towards systematic reviews and other research evidence. Before joining Evidence Aid, Bonnix worked as a physician in DR Congo and Rwanda. He has a strong interest in improving the accessibility of systematic reviews in low-and middle-income countries. Evidence Aid Co-ordinator at the Centre for Global Health
all sessions
D1 Evidence aid
Session: The growing role and impact of Evidence Aid, and its 10-year direction
![]() Bonnix Kayabu Evidence Aid Co-ordinator at the Centre for Global Health 26th Mar 2013 - 15:00
The Cochrane Collaboration’s Evidence Aid project was established by The Cochrane Collaboration following the tsunami in the Indian Ocean in December 2004. It uses knowledge from Cochrane Reviews and other systematic reviews to provide reliable, up-to-date evidence on interventions that might be considered in the context of natural disasters and other major healthcare emergencies. Evidence Aid seeks to highlight which interventions work, which don’t work, which need more research, and which, no matter how well meaning, might be harmful; and to provide this information to agencies and people planning for, or responding to, disasters. Chaired by
Mike Clarke Evidence Aid; Professor/Director of MRC Methodology Hub, Queens University Belfast Chaired by Mike Clarke Evidence Aid; Professor/Director of MRC Methodology Hub, Queens University Belfast | D2 Dealing with hidden data - A new paradigm for systematic reviews? ![]()
An-Wen Chan
Phelan Scientist, Women's College Research Institute, University of Toronto
2013 Dr. An-Wen Chan is a scientist at Women's College Research Institute and an assistant professor of medicine at the University of Toronto. He is also a Mohs surgeon in the Ricky Kanee Schachter Dermatology Program at Women's College Hospital. Dr. Chan is a Rhodes Scholar who completed his sub-specialty surgical fellowship at the Mayo Clinic in Rochester, Minnesota. Dr. Chan has a clinical and research interest in the skin problems of solid organ transplant patients. He directs a specialized transplant dermatology clinic dedicated to skin cancer, infections, and other skin problems in this immunosuppressed patient population. Dr. Chan also studies the epidemiology and innovative treatment of high-risk skin cancers to help reduce their incidence and impact in transplant patients. Dr. Chan is also a recognized expert in clinical trial quality, biases, and methods. He has researched and published extensively on this subject in leading medical journals, and chairs the international SPIRIT Initiative to improve the quality of clinical trial protocols. He served as a Special Advisor to the Clinical Trials Unit of the Canadian Institutes of Health Research and helped coordinate the World Health Organization's International Clinical Trials Registry Platform in Geneva. Phelan Scientist, Women's College Research Institute, University of Toronto
all sessions
D2 Dealing with hidden data - A new paradigm for systematic reviews?
Session: Selective publication and reporting: not things of the past
![]() An-Wen Chan Phelan Scientist, Women's College Research Institute, University of Toronto 26th Mar 2013 - 15:00
The past two decades have been plagued by compelling evidence of patient harms arising from suppression of unfavourable clinical trial results. Despite the implementation of important initiatives to address biased reporting, the trial literature continues to represent a distorted picture of the efficacy and harms of clinical interventions. Additional substantive solutions are needed to ensure that patient care is guided by the totality of existing evidence rather than a select subset of misinformation. ![]()
Tom Jefferson
Editor Cochrane Acute Respiratory Infections Group
2011 2013 Tom is one of the editors of the Cochrane ARI Group, a member of four other review groups, two methods groups and the Cochrane Vaccines Field. His main research interests are the application of systematic reviewing methods to studies of vaccines and antivirals of different designs (such as trials, economic evaluations and epidemiological studies) and peer review. Tom was a visiting fellow at the UK Cochrane Centre in Oxford between 1999 and 2001 and coordinated the Italian National guidelines programme during 2001-2003 and presently is the scientific lead of the Italian HTA programme on devices and diagnostics. While pursuing his research activity, Tom has published over two hundred papers and co-authored five books. Tom has co-reviewed the evidence of the effects of editorial and grant application peer review and the effects of interventions to prevent and treat the common cold (funded by a British Medical Association HC Roscoe Fellowship), of several vaccines and of physical interventions to interrupt transmission of ARIs for a variety of funders. Editor Cochrane Acute Respiratory Infections Group
all sessions
D2 Dealing with hidden data - A new paradigm for systematic reviews?
Session: Bias in neuraminidase inhibitors - are traditional systematic review methods defunct?
![]() Tom Jefferson Editor Cochrane Acute Respiratory Infections Group 26th Mar 2013 - 15:00
A recent survey has shown that only 10% of Cochrane reviews make serious efforts to search for and include unpublished material. Such an approach is no longer tenable as a growing body of evidence shows that reliance of wholly or mostly published data introduces bias in the conclusions of a review and because in the last 2 years the EMA has released over 1.6 million pages of regulatory information. Tom Jefferson will present and discuss some of these issue on the basis of the oseltamivir (Tamiflu) review, starting with the story of how his team realised their previous Cochrane review on Tamiflu were biased and how they went about addressing the problem. Chaired by
Doug Altman Director, Centre for Statistics in Medicine, Oxford Chaired by Doug Altman Director, Centre for Statistics in Medicine, Oxford | D3 Engaging with the internet ![]()
James Quekett
Doctors.net.uk
2010 2013 Dr James Quekett qualified from Bristol University medical school in 1994 qualifying as a General Practitioner in 2000. Over the past 12 years he has been involved with the development of eLearning, initially as an author before joining the team at Doctors.net.uk in 2008. Doctors.net.uk
all sessions
D3 Engaging with the internet
Session: The growing role of social media to facilitate evidence-based practice
![]() James Quekett Doctors.net.uk 26th Mar 2013 - 15:00
Knowledge and evidence is insufficient in changing practice, the uptake of evidence into clinical practice is complex and requires the clinician to be able to place that knowledge within the context of their own work. Producing a guideline is simply not enough. Clinicians need to discuss with each other the 'best fit' for any new evidence and whether they need to do things differently as a result. There may also be a discussion on whether or not the evidence itself is valid. This requires social interaction which has traditionally been done in the face to face environment but now may occur online within social media. ![]()
Jon Brassey
TRIP Database Ltd & Public Health Wales
2011 2013 Jon specialises in understanding and meeting the information needs of clinicians. He works extensively in the world of clinical question answering and has run numerous services. He and his various teams have answered over 10,000 clinical questions. As a result of his work he created and still runs the clinical search engine the TRIP Database (www.tripdatabase.com). The TRIP Database has been running for over ten years and is used worldwide. In 2010 it surpassed 50 million searches since its launch. As well as working on the TRIP Database he works for Public Health Wales also involved in clinical knowledge support. His main current areas of interest include the limitations of search, the personalisation of information (including for the developing world), the use of social media (twitter, blogs) and meeting unknown information needs. TRIP Database Ltd & Public Health Wales
all sessions
D3 Engaging with the internet
Session: Anarchism, Punk and EBM
![]() Jon Brassey TRIP Database Ltd & Public Health Wales 26th Mar 2013 - 15:00
Bringing sex, drugs and rock n roll to the world of EBM! This presentation will link the principles of anarchism and punk to systematic reviews and specifically Cochrane. It will highlight a number of significant problems with the current situation and make some suggestions for changes that are long overdue. The presentation will finish with the question 'Does Cochrane do more harm than good?' Chaired by
Luisa Dillner doc2doc Chaired by Luisa Dillner doc2doc | Workshop & Poster Sessions
all sessions
Workshop & Poster Sessions
Session: Guided Poster Sessions
26th Mar 2013 - 15:00
Guided Poster Sessions... continued from Coffee break Guided poster sessions will run during break times. Posters will be grouped by area of interest, where authors will be taken through a session by a leading expert in the field allowing each two minutes to share their research project. Workshop: How to Teach EBM
all sessions
Workshop & Poster Sessions
Workshop: How to Teach EBM
26th Mar 2013 - 15:00
more details coming soon
Workshop: How to Get Published
all sessions
Workshop & Poster Sessions
Workshop: How to Get Published
26th Mar 2013 - 15:00
more details coming soon
|
| 16:05 | K13 ![]()
Brian Deer
Investigative Reporter
2013 Brian Deer is a British investigative reporter, best known for his inquiries for The Sunday Times, Channel 4 and BMJ into the MMR vaccine scare. A series of his reports over seven years led to the retraction of the original 1998 research in The Lancet, with findings by the General Medical Council of dishonesty by the principal author, and was followed by the restoration of public confidence in Britain and the United States. Deer’s Sunday Times investigations have also included those into the Wellcome Trust, which promptly sold its drug firm subsidiary, Dr Raj Persaud, suspended from medical practice for plagiarism, and Professor Michael Briggs, who drank himself to death after exposure for faking his research on contraceptive pill safety. Deer’s films for Channel 4 have included an investigation into the TGN1412 drug trial disaster of 2006. He has won numerous awards, including two British Press Awards, and the 2011 HealthWatch award. Investigative Reporter
all sessions
K13
Keynote: Taking on the establishment - investigative journalism
![]() Brian Deer Investigative Reporter 26th Mar 2013 - 16:05
Thirty years ago, journalists William Broad and Nicholas Wade sounded the alarm over research fraud with their book Betrayers of the Truth. Today, journalists Adam Marcus and Ivan Oransky carry this forward with the website Retraction Watch. Journalists remain a leading force for integrity. Responses from the biomedical community include indifference and denial. Opinion leaders often justify inaction with conceits, such as “reproducibility” and “peer review”. Journal editors and institutions fail to deal with fraud, misconduct and bogus findings, reluctant to commit resources and fearful of retaliatory litigation. In high-profile areas, research claims impacting safety and health are increasingly evaluated and disseminated by dubious authorities, unqualified consumers and even cranks. To protect the public, the need to remove false and misleading information from the literature has become urgent. I present examples, and suggest amendment to the ICMJE Uniform Requirements so as to facilitate forensic post-publication audit and rapid no-fault retractions. | |||
| 16:50 | AllTrials Campaign and Closing Reflections ![]()
Tracey Brown
Managing Director, Sense About Science
2013 Tracey has been the Director of Sense About Science, a charity that equips people to make sense of evidence, since 2002. She has a background in social research, and previously spent four years working on a European Commission programme to establish social research and teaching in the former Soviet Union. Tracey has written about scientific evidence, policy and the public, for The Times, the Guardian, and a range of periodicals and books, most recently ‘Successful Science Communication’. She is a trustee of Centre of the Cell and the UCL Jill Dando Institute of Security and Crime Science, and a commissioner on the UK Drug Policy Commission. Managing Director, Sense About Science ![]()
Fiona Godlee
Editor in Chief, BMJ
Since 1990 Fiona has written on a broad range of issues for BMJ, including the impact of environmental degradation on health, the future of the World Health Organisation, the ethics of academic publication, and the problems of editorial peer review. In 1994 she spent a year at Harvard University as a Harkness Fellow evaluating efforts to bridge the gap between medical research and practice. On returning to the UK, she led the development of BMJ Clinical Evidence, which evaluates the best available evidence on the benefits and harms of treatments and is now provided worldwide to over a million clinicians in 9 languages. In 2000 she moved to Current Science Group to help establish the open access online publisher BioMedCentral as Editorial Director for Medicine. In 2003 she returned to the BMJ Group to head up its new Knowledge division. She has served as President of the World Association of Medical Editors (WAME) and Chair of the Committee on Publication Ethics (COPE) and is co-editor of Peer Review in Health Sciences. Fiona has been editor in chief of the BMJ since 2005 Editor in Chief, BMJ ![]()
Carl Heneghan
Director, Centre for Evidence-Based Medicine, University of Oxford
Carl Heneghan is the Director of the Centre of Evidence-Based Medicine and a General Practitioner. He has had an association with the Centre for Evidence-Based Medicine since 1995. His research projects involve cardiovascular disease, self-monitoring in chronic diseases, and determining the evidence base for treatment of infections. He is a co-applicant on the £3.5million pound NIHR funded centre for Monitoring and Diagnosis in Oxford (MADOX) and works on projects related to oral anticoagulation, the prevention of venous thrombosis and hypertension management, including self monitoring and tele-monitoring. Director, Centre for Evidence-Based Medicine, University of Oxford | |||
| 17:30 | Close | |||























































































